Description
SNAP-8 Peptide Overview
SNAP-8 Peptide is a synthetic octapeptide developed for cosmetic and peptide research. It is commonly identified as Acetyl Octapeptide-3 and is structurally related to the N-terminal region of SNAP-25, a protein involved in the SNARE complex and neurotransmitter release.
SNAP-8 has attracted interest in cosmetic science because researchers have investigated how short peptide sequences related to SNAP-25 interact with molecular pathways involved in facial-expression-related muscle contraction.
For laboratories and cosmetic formulators, SNAP-8 is particularly relevant to research involving cosmetic peptide formulations, skin-care ingredients, peptide chemistry, stability, and topical delivery systems.
Research Use Only: SNAP-8 Peptide is supplied for laboratory, cosmetic-science, and formulation research purposes only. It is not intended for injection, human or veterinary administration, diagnosis, treatment, cure, or prevention of disease.
What Is SNAP-8 Peptide?
SNAP-8 Peptide, commonly known as Acetyl Octapeptide-3, is a synthetic peptide consisting of eight amino-acid residues with an N-terminal acetyl modification.
It was developed as a longer peptide analogue related to the sequence used in Argireline (Acetyl Hexapeptide-8) research.
The peptide is relevant to studies involving:
- Cosmetic peptide science
- Skin-care formulation research
- Peptide structure and function
- Topical delivery
- Ingredient compatibility
- Peptide stability
- Molecular interaction research
- Cosmetic formulation development
SNAP-8 is frequently discussed alongside other cosmetic peptides, but each peptide has a distinct chemical structure and should be evaluated independently.
Laboratory research results depend on experimental conditions, formulation, concentration, and model system. Research findings should not automatically be interpreted as evidence of clinical effectiveness.
Molecular Formula, Molecular Weight & Sequence
Commonly reported specifications for SNAP-8 / Acetyl Octapeptide-3 include:
| Property | Specification |
|---|---|
| Product name | SNAP-8 Peptide |
| Chemical name | Acetyl Octapeptide-3 |
| Peptide length | 8 amino acids |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| One-letter notation | Ac-EEMQRRAD-NH₂ |
| Molecular formula | C₄₁H₇₀N₁₆O₁₆S |
| Molecular weight | Approximately 1075.2 g/mol |
The acetyl group and C-terminal amidation are important components of the compound’s chemical identity.
Important specification note
SNAP-8 is a modified peptide, so researchers should verify the exact:
Sequence → terminal modifications → molecular formula → molecular weight → observed mass
against the batch-specific COA.
This is particularly important because peptide nomenclature and commercial specifications can vary between suppliers.
Purity
A suitable research-grade specification for SNAP-8 Peptide may be:
Purity: ≥98% by HPLC
The actual purity should always be confirmed through the batch-specific Certificate of Analysis (COA).
A professional analytical package may include:
- HPLC purity percentage
- HPLC chromatogram
- Mass spectrometry
- Calculated molecular weight
- Observed molecular weight
- Lot/batch number
- Testing date
- Net peptide quantity
Researchers should evaluate the analytical data for the actual batch rather than relying exclusively on a general product-page purity claim.
Appearance
Appearance: White to off-white lyophilized powder.
SNAP-8 may be supplied in lyophilized form for controlled laboratory storage and handling.
Minor differences in powder texture or appearance can occur due to manufacturing and drying conditions.
Visual appearance alone does not establish peptide identity or purity. When verification is required, researchers should rely on appropriate analytical methods such as HPLC and mass spectrometry.
Available Vial Sizes
SNAP-8 Peptide can be supplied in several research quantities depending on laboratory and formulation requirements.
Common vial sizes include:
- 5 mg
- 10 mg
- 20 mg
- 50 mg
- 100 mg
For many formulation and laboratory projects, 10 mg and 20 mg formats are convenient research quantities.
Larger quantities can be useful for laboratories performing repeated formulation-development or analytical work.
Always state the net peptide quantity per vial clearly on the product page and product label.
Storage Recommendations
Proper storage helps maintain peptide quality.
For lyophilized SNAP-8:
- Follow the storage conditions provided with the specific batch.
- Keep the vial tightly sealed.
- Protect the material from moisture.
- Minimize exposure to excessive heat.
- Protect from unnecessary direct light.
- Avoid repeated temperature cycling.
- Allow a cold vial to equilibrate appropriately before opening to reduce condensation.
For long-term storage, follow the manufacturer’s validated stability recommendations.
Important: Storage requirements may vary according to formulation, packaging, concentration, and stability data. The batch-specific documentation should take priority.
Reconstitution Information
SNAP-8 is supplied as a lyophilized research material. Preparation should be performed according to the laboratory’s intended application and validated formulation procedure.
General laboratory considerations include:
- Allow the sealed vial to equilibrate appropriately before opening.
- Select a compatible laboratory-grade solvent.
- Introduce the solvent carefully.
- Avoid unnecessarily vigorous agitation.
- Allow sufficient time for dissolution.
- Minimize excessive foaming.
- Record the solvent, concentration, and preparation date.
- Consider aliquoting when appropriate to minimize repeated freeze–thaw exposure.
There is no universal reconstitution volume suitable for every SNAP-8 research or formulation application.
Researchers and formulation scientists should establish preparation conditions according to the exact product specification and intended experimental system.
Intended Use — Research & Cosmetic Formulation
SNAP-8 Peptide is intended for laboratory, cosmetic-science, and formulation research.
Potential research applications include:
- Cosmetic peptide research
- Skin-care formulation development
- Peptide stability studies
- Topical delivery research
- Ingredient compatibility testing
- Peptide chemistry
- Structure–activity relationship studies
It should not be presented as:
- An injectable product
- A prescription medicine
- A medical treatment
- A guaranteed wrinkle treatment
- A dietary supplement
Research Use Only. Not for Human or Veterinary Administration.
Researchers and formulation professionals are responsible for following applicable regulations and laboratory safety requirements.
Packaging & Shipping Information
SNAP-8 Peptide should be packaged appropriately to protect the lyophilized material during transportation.
Professional research packaging may include:
- Securely sealed vial
- Product identification label
- Net peptide quantity
- Lot/batch number
- Research-use statement
- Protective secondary packaging
- Batch-specific COA or analytical documentation, where applicable
Upon receipt, inspect the packaging and vial for visible damage.
Before adding the material to laboratory inventory, verify:
Product name + quantity + lot number + chemical form + COA
Shipping conditions should follow the applicable stability requirements and relevant transportation regulations.
Frequently Asked Questions About SNAP-8 Peptide
What is SNAP-8 Peptide?
SNAP-8 is a synthetic eight-amino-acid peptide commonly identified as Acetyl Octapeptide-3 and researched primarily in cosmetic peptide and formulation science.
What is another name for SNAP-8?
SNAP-8 is commonly known as Acetyl Octapeptide-3.
How many amino acids are in SNAP-8?
SNAP-8 contains eight amino-acid residues.
What is the sequence of SNAP-8?
The commonly reported modified sequence is:
Ac-EEMQRRAD-NH₂
What does “Ac” mean?
Ac represents an N-terminal acetyl modification.
What does “NH₂” mean?
NH₂ indicates a C-terminal amidation.
These modifications are part of the chemical identity of the peptide.
What is the molecular weight of SNAP-8?
The commonly reported molecular weight is approximately 1075.2 g/mol. The exact observed mass should be confirmed against the applicable analytical documentation.
What is SNAP-8 researched for?
SNAP-8 is primarily researched in cosmetic peptide science, skin-care formulation, topical delivery, peptide chemistry, and molecular interaction studies.
What purity should researchers look for?
A research-grade specification may state ≥98% purity by HPLC. The actual batch result should be verified using the COA.
What does SNAP-8 Peptide look like?
Research-grade SNAP-8 is generally supplied as a white to off-white lyophilized powder.
Should SNAP-8 come with a COA?
For professional research supply, batch-specific analytical documentation is highly valuable. Researchers should look for HPLC purity, mass spectrometry, molecular-weight information, lot number, and testing date where available.
How should SNAP-8 be stored?
Follow the storage conditions supplied with the specific batch. Protect the material from moisture, excessive heat, direct light, and unnecessary temperature cycling.
How is SNAP-8 reconstituted?
Preparation depends on the intended formulation, solvent compatibility, concentration, and laboratory protocol. There is no universal reconstitution volume suitable for every application.
Is SNAP-8 the same as Argireline?
No. SNAP-8 and Argireline are different peptide sequences. Argireline is commonly identified as Acetyl Hexapeptide-8, while SNAP-8 is commonly identified as Acetyl Octapeptide-3.
Is SNAP-8 intended for injection?
A research-grade SNAP-8 product should not be presented as an injectable product. It is supplied for laboratory and cosmetic formulation research.
Key Takeaway
SNAP-8 Peptide is a synthetic, modified eight-amino-acid peptide commonly identified as Acetyl Octapeptide-3. It is primarily relevant to cosmetic peptide research, skin-care formulation development, peptide chemistry, and topical delivery studies.
Key commonly reported specifications include:
- Sequence: Ac-EEMQRRAD-NH₂
- Molecular formula: C₄₁H₇₀N₁₆O₁₆S
- Molecular weight: approximately 1075.2 g/mol
- Purity: ≥98% by HPLC as a potential research-grade specification
- Appearance: White to off-white lyophilized powder
For professional research supply, the most important step is verifying the exact chemical identity against the batch-specific COA.
A high-quality SNAP-8 product page should provide accurate specifications, transparent analytical documentation, appropriate storage information, and clear research-use labeling.
Research Use Only. Not for Human or Veterinary Administration.
Continue Learning: If you found this guide helpful, you may also want to read our previous peptide education articles covering the following topics
- Which Peptides Are Beginners Using?
- What Bacteriostatic Water Should I Use For My Peptide?
- What’s Peptide Reconstitution?
- How Should Peptides Be Stored?
- Which peptide suppresses appetite the most?
- Peptide Bubbles after reconstitution?
Scientific Reference: For additional peer-reviewed information on peptide stability, sterile preparation, and pharmaceutical reconstitution practices, visit
National Center for Biotechnology Information (NCBI)
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