Description
Humanin Peptide
Humanin Peptide is a short mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome. It has attracted considerable interest in molecular biology and mitochondrial research because of its relationship with cellular signaling, mitochondrial function, stress-response pathways, and cellular survival mechanisms.
Humanin is particularly interesting because it is a mitochondrial-derived peptide rather than a conventional nuclear-encoded protein fragment. Research has investigated Humanin and its analogues in cellular, metabolic, neurological, and mitochondrial models.
For researchers, accurate characterization is especially important because Humanin may be supplied in different chemical forms, including amidated and non-amidated forms. The exact product specification should therefore always be confirmed using the batch-specific COA.
What Is Humanin Peptide?
Humanin is a small peptide originally identified as a mitochondrial-derived peptide. The commonly studied human Humanin peptide consists of 24 amino acids.
Researchers have investigated Humanin in areas including:
- Mitochondrial biology
- Cellular stress responses
- Peptide signaling
- Cellular survival pathways
- Metabolic research
- Neuroscience
- Oxidative-stress research
- Mitochondrial-derived peptide biology
Humanin is especially useful as a research subject because mitochondrial-derived peptides represent an important area of modern molecular biology.
Unlike many commercially available peptides that are designed from nuclear-encoded proteins, Humanin originates from a short open reading frame within mitochondrial DNA.
Molecular Formula, Molecular Weight & Sequence
Humanin is a defined 24-amino-acid peptide.
Commonly reported Humanin sequence
MAPRGFSCLLLLTSEIDLPVKRRA
One-letter sequence:
MAPRGFSCLLLLTSEIDLPVKRRA
| Property | Specification |
|---|---|
| Product name | Humanin Peptide |
| Peptide type | Mitochondrial-derived peptide |
| Length | 24 amino acids |
| Sequence | MAPRGFSCLLLLTSEIDLPVKRRA |
| Molecular formula | Depends on chemical form |
| Molecular weight | Approximately 2.68 kDa for the commonly referenced peptide form |
| Research classification | Synthetic research peptide |
Important formulation note
The exact molecular formula and molecular weight can differ depending on the terminal chemical form.
For example, an amidated peptide and a free-acid peptide do not have identical molecular masses.
Therefore, your product page should use the exact molecular weight and formula supplied on your manufacturer’s COA rather than assuming that every Humanin product has identical specifications.
For research-grade material, mass spectrometry is useful for confirming the expected molecular mass.
Purity
A commonly requested specification for research-grade Humanin Peptide is:
Purity: ≥98% by HPLC
However, the exact purity claim should correspond to the specific batch being supplied.
A professional COA may include:
- HPLC purity percentage
- HPLC chromatogram
- Mass spectrometry
- Expected molecular weight
- Observed molecular weight
- Lot/batch number
- Testing date
- Peptide content
For maximum transparency, researchers should review the batch-specific COA rather than relying solely on a general product-page statement.
Appearance
Typical appearance: White to off-white lyophilized powder.
Humanin is commonly supplied as a dry, lyophilized research peptide.
Minor variations in powder appearance can occur because of manufacturing and lyophilization conditions.
Visual inspection alone cannot confirm peptide identity or purity. Researchers requiring identity confirmation should rely on appropriate analytical testing, such as HPLC and mass spectrometry.
Available Vial Sizes
Humanin Peptide can be offered in several quantities depending on laboratory requirements.
Common research formats include:
- 5 mg
- 10 mg
- 20 mg
- 50 mg
- 100 mg
For many laboratory applications, smaller quantities such as 5 mg and 10 mg may be practical starting formats, while larger quantities can support repeated experimental work.
Only advertise vial sizes that you actually stock and can support with appropriate documentation.
The label should clearly identify:
Humanin + quantity + chemical form + lot number
Storage Recommendations
Proper storage is important for maintaining the quality of lyophilized Humanin.
General laboratory considerations include:
- Keep the vial tightly sealed.
- Protect the peptide from moisture.
- Minimize unnecessary exposure to heat.
- Protect from excessive direct light.
- Avoid repeated temperature fluctuations.
- Follow the manufacturer’s recommended storage conditions.
- Allow refrigerated or frozen material to equilibrate appropriately before opening to minimize condensation.
For long-term storage, follow the stability information supplied for the specific batch.
Once reconstituted, stability may differ significantly from the original lyophilized material.
Researchers should therefore establish post-reconstitution storage conditions according to their validated laboratory procedures.
Reconstitution Information
Humanin is generally supplied as a lyophilized peptide.
Reconstitution should be performed according to the intended laboratory application and the properties of the specific formulation.
General considerations include:
- Allow the sealed vial to equilibrate appropriately before opening.
- Select a compatible laboratory solvent.
- Add the solvent carefully.
- Avoid unnecessarily vigorous shaking or vortexing.
- Allow adequate time for dissolution.
- Record the solvent and final concentration.
- Minimize unnecessary freeze–thaw exposure.
- Follow the applicable stability protocol after preparation.
There is no universal reconstitution volume appropriate for every Humanin research experiment.
The appropriate concentration and solvent depend on the experimental design, analytical requirements, and validated laboratory procedures.
Intended Use — Research Only
Humanin Peptide is intended for laboratory and scientific research.
Potential research areas include:
- Mitochondrial-derived peptide research
- Mitochondrial biology
- Cellular signaling
- Cellular stress-response studies
- Oxidative-stress research
- Metabolic research
- Neuroscience
- Peptide structure and function
- Molecular biology
Humanin should not be marketed as:
- An anti-aging treatment
- A longevity therapy
- A treatment for neurological disease
- A metabolic treatment
- A prescription medicine
- A supplement
- A guaranteed method for improving human health
Research Use Only. Not for Human or Veterinary Administration.
Researchers are responsible for ensuring that their experimental use complies with applicable laws, institutional requirements, and laboratory safety procedures.
Packaging & Shipping Information
Professional packaging helps protect Humanin during transportation and provides researchers with important identification information.
Packaging may include:
- Securely sealed vial
- Product identification label
- Net quantity
- Chemical form where applicable
- Lot/batch number
- Research-use statement
- Protective secondary packaging
- Batch-specific COA
Upon receipt, inspect the vial and packaging for visible damage.
Before placing the material into laboratory inventory, verify:
Product name + quantity + chemical form + lot number + COA
Shipping conditions should follow the product’s documented stability requirements and applicable transportation regulations.
Frequently Asked Questions About Humanin Peptide
What is Humanin Peptide?
Humanin is a short mitochondrial-derived peptide that has been investigated in cellular, mitochondrial, metabolic, and neuroscience research.
How many amino acids are in Humanin?
The commonly studied Humanin sequence contains 24 amino acids.
What is the Humanin sequence?
The commonly reported sequence is:
MAPRGFSCLLLLTSEIDLPVKRRA
What is the molecular weight of Humanin?
The molecular weight is approximately 2.68 kDa, although the exact value depends on the chemical form of the peptide.
Why can Humanin’s molecular weight vary?
Different terminal modifications or chemical forms can change the molecular mass. Researchers should therefore verify the exact value using the product’s COA.
What purity should researchers look for?
A research-grade product may specify ≥98% HPLC purity. The actual purity should always be verified against the batch-specific analytical report.
What does Humanin Peptide look like?
It is typically supplied as a white to off-white lyophilized powder.
What is Humanin researched for?
Humanin has been studied in mitochondrial biology, cellular signaling, stress-response pathways, metabolism, neuroscience, and mitochondrial-derived peptide research.
Should Humanin come with a COA?
Yes. For professional research applications, a batch-specific COA is highly valuable. It can provide HPLC purity, mass spectrometry, molecular-weight information, lot number, and testing date.
How should Humanin be stored?
Follow the manufacturer’s specifications for the particular batch. Protect the lyophilized peptide from moisture, excessive heat, unnecessary light exposure, and repeated temperature fluctuations.
How is Humanin reconstituted?
Reconstitution depends on the research application, solvent compatibility, and desired concentration. There is no universal preparation protocol suitable for every experiment.
Is Humanin an anti-aging peptide?
Humanin has been investigated in aging-related and cellular biology research, but research-grade Humanin should not be represented as an approved anti-aging or longevity treatment.
Is Humanin intended for human use?
No. A research-grade Humanin product should be clearly labeled:
Research Use Only — Not for Human or Veterinary Administration.
Key Takeaway
Humanin Peptide is a 24-amino-acid mitochondrial-derived peptide that has become an important subject in modern mitochondrial and molecular biology research.
Key product specifications
- Sequence: MAPRGFSCLLLLTSEIDLPVKRRA
- Length: 24 amino acids
- Molecular weight: approximately 2.68 kDa, depending on chemical form
- Purity: ≥98% by HPLC when supported by the applicable COA
- Appearance: White to off-white lyophilized powder
- Format: Research-grade peptide
- Intended use: Laboratory research only
For researchers, the most important purchasing considerations are verified identity, documented purity, correct chemical form, batch-specific analytical testing, and reliable storage information.
Because the exact molecular weight can vary with terminal modifications, your final product listing should match the specific chemical form and COA of the Humanin you actually sell.
Research Use Only. Not for Human or Veterinary Administration.
Continue Learning: If you found this guide helpful, you may also want to read our previous peptide education articles covering the following topics
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- Peptide Bubbles after reconstitution?
- Are peptides legal?
- What Does HPLC Testing Mean?
- How do I read a COA?
- How Should Peptides Be Stored?
- What’s Peptide Reconstitution?
Scientific Reference: For additional peer-reviewed information on peptide stability, sterile preparation, and pharmaceutical reconstitution practices, visit
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