Description

Matrixyl Peptide Overview

Matrixyl Peptide is a commonly used name associated with peptide ingredients developed for cosmetic and skin-care research. Importantly, Matrixyl is a trademarked ingredient family rather than one single chemical substance. Different Matrixyl-branded materials contain different peptide sequences and chemical forms.

One of the best-known Matrixyl ingredients is Palmitoyl Pentapeptide-4, historically associated with the Matrixyl brand. Other Matrixyl products, such as Matrixyl 3000 and Matrixyl Synthe’6, contain different peptide combinations.

For a product page, it is therefore important to identify the exact Matrixyl peptide being supplied rather than treating all Matrixyl products as chemically identical.

The information below focuses on Palmitoyl Pentapeptide-4, commonly associated with the original Matrixyl ingredient.

Research Use Only: Matrixyl Peptide is supplied for laboratory, cosmetic-science, and formulation research purposes. It is not intended for human or veterinary administration, diagnosis, treatment, cure, or prevention of disease.

What Is Matrixyl Peptide?

Matrixyl Peptide, when referring to the original Matrixyl ingredient, is commonly identified as Palmitoyl Pentapeptide-4.

It is a lipidated peptide, meaning a palmitoyl fatty-acid chain is attached to the peptide structure. This modification influences the compound’s physicochemical properties and makes it particularly relevant to topical cosmetic formulation research.

The peptide portion is derived from a sequence associated with extracellular matrix proteins, and researchers have investigated the ingredient in relation to skin-supporting cosmetic formulations and matrix-related biological processes.

Research applications can include:

• Cosmetic peptide formulation
• Skin-care ingredient research
• Peptide stability studies
• Topical delivery research
• Extracellular matrix research
• Structure–activity relationship studies
• Peptide characterization
• Cosmetic ingredient compatibility testing

Important: “Matrixyl” can refer to several different commercial peptide formulations. Always match the product name to the exact material and COA supplied.

Molecular Formula, Molecular Weight & Sequence

For Palmitoyl Pentapeptide-4, commonly associated with the original Matrixyl ingredient:

The Pal portion represents the palmitoyl fatty-acid modification attached to the peptide.

Why the exact Matrixyl identity matters

Matrixyl is a brand/ingredient family, not a single universal chemical structure.

For example, Palmitoyl Pentapeptide-4, Matrixyl 3000, and Matrixyl Synthe’6 should not be presented as interchangeable products because their compositions and peptide components differ.

For your product page, verify:

Exact ingredient → sequence → modification → molecular formula → molecular weight → COA

before publishing the specification.

Purity

A suitable research-grade specification for a purified peptide material may be:

Purity: ≥98% by HPLC

The actual purity should always be confirmed through the batch-specific Certificate of Analysis (COA).

Depending on the testing package, analytical documentation may include:

• HPLC purity percentage
• HPLC chromatogram
• Mass spectrometry
• Calculated molecular weight
• Observed molecular weight
• Lot/batch number
• Testing date
• Net peptide quantity

For professional research, the COA should correspond to the exact chemical form and lot supplied.

Appearance

Appearance: White to off-white lyophilized powder.

Because Palmitoyl Pentapeptide-4 contains a hydrophobic palmitoyl group, its physical properties can differ from those of an unmodified peptide.

Minor variations in powder appearance or texture may occur between batches.

Visual appearance alone cannot confirm identity or purity. Researchers should use analytical testing such as HPLC and mass spectrometry when verification is required.

Available Vial Sizes

Matrixyl Peptide can be offered in different research quantities depending on laboratory and formulation requirements.

Common vial sizes include:

• 5 mg
• 10 mg
• 20 mg
• 50 mg
• 100 mg

For smaller formulation and laboratory projects, 10 mg and 20 mg quantities may be convenient.

Larger quantities can be appropriate for repeated formulation-development or analytical work.

Always clearly display the net peptide quantity per vial on the product page and label.

Storage Recommendations

Proper storage helps maintain peptide quality.

For lyophilized Palmitoyl Pentapeptide-4:

• Follow the storage conditions provided with the specific batch.
• Keep the container tightly closed.
• Protect from moisture.
• Minimize exposure to excessive heat.
• Protect from unnecessary direct light.
• Avoid repeated temperature cycling.
• Allow a cold vial to equilibrate appropriately before opening to reduce condensation.

For long-term storage, follow the manufacturer’s validated stability recommendations.

Important: Exact storage requirements may vary according to purity, formulation, packaging, and stability data. The batch-specific documentation should take priority.

Reconstitution Information

Matrixyl Peptide is supplied as a lyophilized research material.

Because Palmitoyl Pentapeptide-4 contains a hydrophobic palmitoyl group, its solubility can differ from that of conventional water-soluble peptides.

General laboratory considerations include:

1. Allow the sealed vial to reach an appropriate temperature before opening.
2. Select a solvent compatible with the intended research or formulation system.
3. Add the solvent carefully.
4. Avoid unnecessarily vigorous agitation.
5. Allow sufficient time for dissolution.
6. Record the solvent and final concentration.
7. Consider aliquoting where appropriate.
8. Follow validated stability procedures after preparation.

There is no universal reconstitution volume or solvent suitable for every Matrixyl research application.

Researchers and formulation scientists should determine preparation conditions based on the exact product specification and intended formulation.

Intended Use — Research & Cosmetic Formulation

Matrixyl Peptide is intended for laboratory and cosmetic formulation research.

Potential applications include:

• Cosmetic ingredient research
• Skin-care formulation development
• Peptide stability testing
• Topical formulation research
• Peptide chemistry
• Extracellular matrix research
• Ingredient compatibility studies

It should not be marketed as:

• An injectable product
• A prescription medicine
• A guaranteed anti-aging treatment
• A treatment for wrinkles or skin disease
• A dietary supplement

Research Use Only. Not for Human or Veterinary Administration.

Researchers and formulation professionals are responsible for complying with applicable regulations and safety requirements.

Packaging & Shipping Information

Matrixyl Peptide should be packaged appropriately to protect the material during transportation.

Professional research packaging may include:

• Securely sealed vial
• Product identification label
• Net peptide quantity
• Lot/batch number
• Research-use statement
• Protective secondary packaging
• Batch-specific COA or analytical documentation, where applicable

Upon receipt, inspect the package and vial for visible damage.

Before adding the material to laboratory inventory, verify:

Product name + quantity + lot number + chemical form + COA

Shipping conditions should follow the applicable stability requirements and relevant transportation regulations.

Frequently Asked Questions About Matrixyl Peptide

What is Matrixyl Peptide?

Matrixyl is a family of cosmetic peptide ingredients. When referring to the original Matrixyl ingredient, it commonly means Palmitoyl Pentapeptide-4.

Is Matrixyl one specific peptide?

Not necessarily. Matrixyl is a branded ingredient family, and different Matrixyl products can contain different peptide compositions.

What is the sequence of Palmitoyl Pentapeptide-4?

The commonly reported structure is:

Pal-Gly-Gln-Pro-Arg

or:

Pal-GQPR

What does “Pal” mean?

Pal refers to a palmitoyl fatty-acid modification attached to the peptide.

What is the molecular formula?

For Palmitoyl Pentapeptide-4, a commonly reported formula is:

C₃₄H₆₂N₈O₇

What is the molecular weight?

The commonly reported molecular weight is approximately:

718.93 g/mol

What is the CAS number?

Palmitoyl Pentapeptide-4 is commonly identified as:

CAS 214047-00-4

What does Matrixyl Peptide look like?

Purified research-grade material may be supplied as a white to off-white lyophilized powder.

What purity should researchers look for?

A research-grade specification may state ≥98% purity by HPLC. The actual batch result should be confirmed using the COA.

Is Matrixyl the same as Matrixyl 3000?

No. Matrixyl 3000 is a different commercial peptide system containing multiple peptide components. The exact composition should be confirmed before listing or selling the product.

Should Matrixyl Peptide come with a COA?

For professional research supply, batch-specific analytical documentation is highly valuable. Researchers should look for HPLC purity, mass spectrometry, molecular-weight information, lot number, and testing date where available.

How should Matrixyl Peptide be stored?

Follow the storage instructions provided with the specific batch. Protect the material from moisture, excessive heat, direct light, and unnecessary temperature cycling.

How is Matrixyl Peptide reconstituted?

Preparation depends on the exact chemical form, solvent system, desired concentration, and intended formulation. There is no universal reconstitution method suitable for every application.

Is Matrixyl Peptide intended for injection?

No. A research-grade Matrixyl peptide should not be presented as an injectable product. It is supplied for laboratory and formulation research.

Key Takeaway

Matrixyl Peptide, when referring to the original Matrixyl ingredient, is commonly identified as Palmitoyl Pentapeptide-4, a lipidated five-amino-acid peptide investigated extensively in cosmetic and formulation research.

Key specifications commonly associated with Palmitoyl Pentapeptide-4 include:

• Peptide sequence: Pal-GQPR
• Molecular formula: C₃₄H₆₂N₈O₇
• Molecular weight: approximately 718.93 g/mol
• Purity: ≥98% by HPLC as a potential research-grade specification
• Appearance: White to off-white lyophilized powder

The most important consideration when listing Matrixyl Peptide online is to identify the exact Matrixyl ingredient being supplied. Matrixyl, Matrixyl 3000, and other Matrixyl-branded ingredients are not chemically identical.

For a professional product page, always verify the exact product identity against the batch-specific COA, including sequence, chemical modification, molecular weight, purity, and analytical results.

Research Use Only. Not for Human or Veterinary Administration.

Continue Learning: If you found this guide helpful, you may also want to read our previous peptide education articles covering the below topics

• Which peptide suppresses appetite the most? 
• Peptide Bubbles after reconstitution?
• Peptide Purity explained in depth
• What Does HPLC Testing Mean?
• How Should Peptides Be Stored?
• What’s Peptide Reconstitution?

Scientific Reference: For additional peer-reviewed information on peptide stability, sterile preparation, and pharmaceutical reconstitution practices, visit

PubMed

United States Pharmacopeia (USP) – USP <797> Sterile Compounding

National Center for Biotechnology Information (NCBI)